API
Milo Biotech: Your Premier Amino Acids Supplier
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We are China's leading professional raw material supplier with more than 10 years of export experience, providing manufacturers with one-stop supply solutions from raw materials to delivery.
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What is API
Active pharmaceutical ingredients (APIs) are the chemical-based compounds that have produced mainly in the countries the USA, Europe, China, and India. APIs have pharmacological activity mainly used with combination of other ingredients to diagnose, cure, mitigate, and treat the disease. However, in the recent past years, many medicinal-based corporations have started importing these substances from countries producing active ingredients to their home countries.
We have more than ten years of experience in the human nutrition, animal additives and cosmetic raw material industries. Let me introduce you to several hot-selling API products!
Why Choose PQQ Powder From Us
PQQ Disodium Salt is very stable, has a 3-year shelf life, and can easily be incorporated into powdered drink mixes, tablets, capsules, chewables, effervescent tablets, candy, and gummies. PQQ Acid can be incorporated into oil based products like chocolates, soft gels, and tinctures. PQQ Acid can also be emulsified for incorporation into ready-to-drink beverages and other water based foods and beverages.
PQQ is available as a stand alone dietary supplement, or in combination with synergistic ingredients like CoQ10. It is also available in powdered drink mixes and ready-to-drink beverages for sports nutrition.
How Does PQQ Work
Mitochondrial Growth & ATP Production
Mitochondria are the powerhouses of the cell and produce the vast majority of all cellular energy (ATP). PQQ activates a key transcription factor protein (CREB) and directly stimulates Mitochondrial Biogenesis, which is the growth and replication of new mitochondria. Stronger mitochondria, and more of them, produce more cellular ATP and thereby, users of PQQ may feel higher levels of natural energy.
Powerful Antioxidant Protection
Antioxidants protect your cells from damage inflicted by harmful molecules called free radicals. PQQ is an extremely potent antioxidant and is approximately 100 times more effective than Vitamin C at reducing these free radicals. A continuous supply of PQQ provides long-lasting protection and promotes the longevity of your heart, brain, liver and other organs rich in mitochondria.
Nerve Cells Support
Nerve Growth Factor (NGF) is a small protein that plays a critical role in the growth, development and maintenance of neurons. PQQ has been found to promote NGF production, with one study showing as much as a 40x increase. Increased levels of NGF help to maintain the health of the brain and peripheral nerves while also stimulating nerve regeneration. This promotes more mental energy, greater focus, and better short-term memory.
Benefits of PQQ Powder
Antioxidant
When your body breaks down food into energy, it also makes free radicals. Antioxidants fight free radicals. PQQ is an antioxidant and based on research, it shows to be more powerful at fighting free radicals than vitamin C. Antioxidants work better together, so it’s unclear if taking PQQ alone as a supplement can help stop any diseases.
Mitochondrial Dysfunction
Mitochondria are the power centers of your cells. Problems with your mitochondria can lead to heart problems, diabetes, and cancer. One study tested PQQ supplements in men who did aerobic exercise for 6 weeks. It increased mitochondria by affecting certain proteins during exercise. Another study showed that dietary PQQ raised mitochondria activity.
Anti-diabetes
Problems with mitochondria are part of what causes diabetes. Lifestyle choices like exercise, food, stress, and sleep affect mitochondrial health. Animal data shows that PQQ supplements fix mitochondrial problems from diabetes and make diabetic mice respond better to insulin. Yet, there isn’t any evidence that PQQ can help people with diabetes.
Anti-diabetes
Problems with mitochondria are part of what causes diabetes. Lifestyle choices like exercise, food, stress, and sleep affect mitochondrial health. Animal data shows that PQQ supplements fix mitochondrial problems from diabetes and make diabetic mice respond better to insulin. Yet, there isn’t any evidence that PQQ can help people with diabetes.
Nootropic
Substances that help memory, attention, and learning are sometimes called nootropics. Studies show that PQQ raises blood flow to the cerebral cortex. This is the part of your brain that helps with attention, thinking, and memory. This supplement also may also memory problems in older people.
Dosage And Possible Side Effects of PQQ Powder
When considering things like dosage and adverse effects, bear in mind that PQQ hasn’t been rigorously tested in humans.
Dosage
Due to a lack of robust data, no set PPQ dosage recommendation exists. However, the available research suggests that results may be seen from doses as low as 5 mg per day.
Adverse Effects
Likewise, its side effects aren’t fully known, as very few human studies have examined this substance. Yet, toxicology studies indicate that PQQ poses a risk of kidney damage when taken at very high doses. As such, you shouldn’t take more than the amount recommended on the packaging.
It’s still unclear whether PQQ interacts negatively with any medications. Consult your healthcare provider prior to adding PQQ to your supplement regimen, especially if you’re taking any other medications or supplements.
CAS: 23111-00-4
Source: Synthetic
Molecular Formula: C1H15CIN2O5
Molecular Weight: 290.7 g/mol
Appearance: White to off-white powder
Storage Temp: 2-8°C
Assay: ≥97% (HPLC)
Package: 1kg/bag, 25kg/drum, or as per customer's requirement
Benefits of Nicotinamide Riboside Chloride Powder
Support for Cellular Energy Production
The primary cellular targets of NR are NAD+ and the sirtuin proteins. NAD+ is nicotinamide adenine dinucleotide - a coenzyme important for the conversion of food into cellular fuel. Foods must be digested down to their smallest metabolic components – sugars, fats, and amino acids. The mitochondria in our cells make cellular energy that fuel the many biochemical processes that occur within the cell.
Support for Brain Function
Increasing NAD+ and the sirtuin proteins in brain cells and nerves stimulates enzymes that support cognitive function and neuroplasticity - the ability of our brain cells to learn and adapt to their environment. This also increases the activity of an enzyme called PCG-1-alpha, which stimulates our cells to create more mitochondria in the cells.
Support for Healthy Metabolic Function
When NAD+ and the sirtuins are up-regulated, our cells are more metabolically active and more efficient at converting food to fuel. This helps us more effectively use insulin, cholesterol, and maintain a normal inflammatory response.
Support for Normal Liver Function
When we support NAD+ production and mitochondrial function we support the cells of the liver and reduce the potential for fat to deposit in the liver. We also promote a normal inflammatory response.
Support for Exercise Efficiency
NAD+ is a key component in the Krebs cycle and electron transport chain. Adequate amounts of NAD+ improve mitochondrial energetics in the heart and muscles, and boost production of energy-creating ATP, which provides support for endurance athletes and fatigued individuals.
Support for Healthy Aging
Supporting NAD+ production and the sirtuin proteins has been shown in animal studies to slow the processes associated with aging. Although nothing really works as an “anti-aging” supplement, helping the sirtuins, NAD+, and the mitochondria supports healthy aging.
When Taken By Mouth: Nicotinamide riboside chloride is possibly safe when used in doses up to 300 mg daily. Side effects are usually mild and might include nausea, bloating, and skin problems such as itching and sweating.
Pregnancy And Breast-Feeding: Nicotinamide riboside chloride is possibly safe when used in doses up to 230 mg by mouth daily while pregnant or breast-feeding.
Nicotinamide riboside is likely safe with few - if any - side effects.
In human studies, taking 1,000–2,000 mg per day had no harmful effects (28Trusted Source, 29Trusted Source). However, most human studies are short in duration and have very few participants. For a more accurate idea of its safety, more robust human studies are needed.
Some people have reported mild to moderate side effects, such as nausea, fatigue, headaches, diarrhea, stomach discomfort and indigestion. In animals, taking 300 mg per kg of body weight (136 mg per pound) daily for 90 days had no harmful effects. What’s more, unlike vitamin B3 (niacin) supplements, nicotinamide riboside should not cause facial flushing.
CAS Number: 1077-28-7
Synonyms: DL-Thioctic Acid
Formula: C8H14O2S2
Molecular Weight: 206.33 g/mol
Appearance: Fine crystalline powder
Purity / Analysis Method: >99.0%(T)
Storage Temperature: 0-10°C
Package: 1kg, 25kg, or customized packaging available
1.It is an organic pure sodium salt with high quality for human body absorption.
2.Our lipoic acid powder is completely free of the less potent S-form.
3.As an antioxidant, the ingredients are stable and leave no residue.
4.Provides antioxidant benefits in water-soluble and fat-soluble forms.
5.Suitable for vegetarians and no genetic engineering techniques are used.
Benefits of Alpha-Lipoic Acid
Weight Loss
ALA's ability to enhance calorie burning and promote weight loss has been exaggerated by many diet gurus and supplement manufacturers. An additional meta-analysis published in 2020 found that treatment with ALA significantly reduced body mass index and reduced weight by about 5 pounds as compared to a placebo.
Diabetes
ALA may aid in the control of glucose by speeding up the metabolism of blood sugar. This could potentially help manage diabetes, a disease characterized by high blood glucose levels. A 2018 review of 20 randomized controlled trials looked at ALA use in people with metabolic disorders, including type 2 diabetes. Results showed ALA supplementation lowered fasting blood glucose, insulin concentration, insulin resistance, and hemoglobin A1C levels.
Nerve Pain
A clinical trial published in 2021 found that people with pain from unknown causes reported less severe pain scores when they took between 400 milligrams and 800 milligrams of an oral ALA supplement compared to those who took a placebo. A review of studies concluded that the antioxidant properties of alpha lipoic acid could be helpful in managing neuropathic pain, though it also noted that clinical studies have so far been inconsistent in things like dosing and treatment protocols.
Nerve Pain
A clinical trial published in 2021 found that people with pain from unknown causes reported less severe pain scores when they took between 400 milligrams and 800 milligrams of an oral ALA supplement compared to those who took a placebo. A review of studies concluded that the antioxidant properties of alpha lipoic acid could be helpful in managing neuropathic pain, though it also noted that clinical studies have so far been inconsistent in things like dosing and treatment protocols.
Special Precautions and Warnings of ALA Powder
When Taken by Mouth: Alpha-lipoic acid is possibly safe for most adults when taken for up to 4 years. It is usually well-tolerated. The most common side effects are headache, heartburn, nausea, and vomiting.
When Applied to the Skin: Alpha-lipoic acid is possibly safe for most adults when used as a cream for up to 12 weeks. It might cause a rash in some people. Pregnancy: When taken by mouth, alpha-lipoic acid is possibly safe. It's been used safely during pregnancy in doses of up to 600 mg daily for up to 4 weeks.
Breast-feeding: There isn't enough reliable information to know if alpha-lipoic acid is safe to use when breast-feeding. Stay on the safe side and avoid use.
Children: Alpha-lipoic acid is possibly safe in children aged 10-17 years when taken by mouth in doses up to 600 mg daily for 3 months. But it is possibly unsafe for children to take large amounts of alpha-lipoic acid by mouth. Seizures, vomiting, and unconsciousness have been reported for children aged 14 months to 16 years who took up to 2400 mg of alpha-lipoic acid as a single dose.
Our Factory
Shaanxi Milo Biotech Co., Ltd. is a global, technical and professional nutritional health supplement company with complete production processes and standardized inspection processes to ensure product quality and consistency.
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Our Certificate
We have passed the international certification system, obtained industry certificates, provided customers with high-quality products, and can also provide customers with third-party testing reports.
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Frequently Asked Questions
Q: What does API mean in formulation?
Q: What is an example of an API ingredient?
Q: What is an active ingredient in a drug?
Q: What is pharmaceutically active ingredient?
Q: Do all drugs have active ingredients?
Q: What is the difference between drug substance and active pharmaceutical ingredient?
Q: What are examples of natural active pharmaceutical ingredients?
Q: Is paracetamol an API?
Q: What does PQQ do for your body?
Q: How can I get PQQ naturally?
Q: Is PQQ the same as CoQ10?
Q: Is PQQ safe to take daily?
Q: Should I take PQQ in the morning or at night?
Q: What is the mechanism of action of PQQ?
Q: Does PQQ deplete glutathione?
Q: Does PQQ increase glutathione?
Q: What is nicotinamide riboside chloride good for?
Q: Is vitamin B3 the same as nicotinamide riboside?
Q: What is the difference between nicotinamide riboside and nicotinamide riboside chloride?
Q: Who should not take nicotinamide riboside?
Q: How do you use alpha lipoic acid powder?
Q: What is the purpose of taking alpha-lipoic acid?
Q: What is the best form of alpha-lipoic acid to take?
Q: What are the benefits of taking alpha-lipoic acid daily?